Refrigerants such as ammonia, carbon dioxide and non-halogenated hydrocarbons do not deplete the ozone layer and have no (ammonia) or only a low (carbon dioxide, hydrocarbons) global warming potential.

They are used in air-conditioning systems for buildings, in sport and leisure facilities, in the chemical/pharmaceutical industry, in the automotive industry and above all in the food industry (production, storage, retailing). In these settings their toxicity is less a concern than in home equipment.